:root{--font-geist-sans:Inter, ui-sans-serif, -apple-system, BlinkMacSystemFont, "Segoe UI", sans-serif;--font-geist-mono:"SFMono-Regular", Consolas, "Liberation Mono", monospace;--ink:#0a1730;--navy:#08152c;--navy-soft:#112342;--blue:#1688b5;--cyan:#38bde8;--mint:#58cbb0;--coral:#ff826e;--paper:#f4f5f2;--white:#fff;--muted:#6d7785;--line:#dfe3e5;--line-dark:#ffffff1f;--sidebar:256px}*{box-sizing:border-box}html{background:var(--paper);scroll-behavior:smooth;scroll-padding-top:28px}body{background:var(--paper);min-width:320px;color:var(--ink);font-family:var(--font-geist-sans), Arial, sans-serif;margin:0;font-size:15px;overflow-x:hidden}button,input{font:inherit}button{color:inherit}button:focus-visible,[data-tooltip]:focus-visible{outline-offset:3px;outline:3px solid #38bde873}.app-shell{min-height:100vh}.sidebar{z-index:20;width:var(--sidebar);color:#eaf1f8;background:radial-gradient(circle at 30% 8%, #2994b72e, transparent 24%), var(--navy);flex-direction:column;padding:28px 20px 22px;display:flex;position:fixed;inset:0 auto 0 0;overflow:hidden auto}.brand{align-items:center;gap:12px;width:fit-content;margin:0 10px 46px;display:flex}.brand-mark{width:38px;height:38px;color:var(--cyan);background:#38bde814;border:1px solid #6fdaf08a;border-radius:10px 10px 10px 2px;place-items:center;font-weight:760;display:grid}.brand strong,.brand small,.profile strong,.profile small{display:block}.brand strong{color:#fff;letter-spacing:-.02em;font-size:16px}.brand small{color:#8fa1b8;letter-spacing:.16em;text-transform:uppercase;margin-top:1px;font-size:11px}.nav-label{color:#667a96;letter-spacing:.16em;margin:0 12px 12px;font-size:10px;font-weight:700}.nav-item{color:#99aac0;cursor:pointer;text-align:left;background:0 0;border:0;border-radius:9px;align-items:center;gap:13px;width:100%;padding:12px 14px;transition:color .15s,background .15s,transform .15s;display:flex}.nav-item+.nav-item{margin-top:5px}.nav-item:hover{color:#e7f0f8;background:#ffffff0b;transform:translate(2px)}.nav-item.active{color:#fff;box-shadow:inset 2px 0 var(--cyan);background:linear-gradient(90deg,#2697be3d,#2697be0f)}.nav-index{color:var(--cyan);font-family:var(--font-geist-mono), monospace;font-size:11px}.sidebar-spacer{flex:1}.sidebar-note{border:1px solid var(--line-dark);background:#ffffff06;border-radius:10px;gap:10px;padding:14px 12px;display:flex}.sidebar-note strong{font-size:12px;font-weight:650}.sidebar-note p{color:#8698af;margin:5px 0 0;font-size:11px;line-height:1.45}.pulse-dot{background:var(--mint);border-radius:999px;flex:0 0 8px;width:8px;height:8px;margin-top:4px;box-shadow:0 0 0 5px #58cbb01a}.sidebar-method{color:#afbdd0;cursor:pointer;text-align:left;background:0 0;border:0;align-items:center;gap:9px;margin:11px 0 20px;padding:10px 12px;font-size:12px;display:flex}.info-symbol{border:1px solid;border-radius:50%;flex:0 0 19px;place-items:center;width:19px;height:19px;font-family:Georgia,serif;font-size:12px;font-style:italic;font-weight:700;display:inline-grid}.profile{border-top:1px solid var(--line-dark);align-items:center;gap:10px;padding-top:18px;display:flex}.avatar{width:35px;height:35px;color:var(--navy);background:#dfe8e7;border-radius:50%;place-items:center;font-size:11px;font-weight:750;display:grid}.profile strong{color:#fff;font-size:12px}.profile small{color:#7e91aa;margin-top:3px;font-size:9px}main{min-width:0;min-height:100vh;margin-left:var(--sidebar)}.topbar{z-index:12;border-bottom:1px solid var(--line);-webkit-backdrop-filter:blur(18px);backdrop-filter:blur(18px);background:#f4f5f2eb;justify-content:space-between;align-items:center;height:72px;padding:0 42px;display:flex;position:sticky;top:0}.topbar>div,.topbar-actions{align-items:center;gap:10px;display:flex}.topbar span,.topbar strong,.topbar b{letter-spacing:.13em;font-size:10px}.topbar>div:first-child span,.topbar b{color:#94a0aa}.topbar b{font-weight:400}.privacy-pill{color:#4d6d65;text-transform:none;background:#ffffffb3;border:1px solid #d6dedb;border-radius:999px;align-items:center;gap:7px;padding:8px 11px;display:inline-flex;letter-spacing:.04em!important}.lock-dot{background:var(--mint);border-radius:50%;width:7px;height:7px}.icon-button{border:1px solid var(--line);color:#536272;cursor:pointer;background:#ffffffb3;border-radius:50%;place-items:center;width:32px;height:32px;font-family:Georgia,serif;font-style:italic;font-weight:700;display:grid}.content{width:min(1220px,100% - 64px);margin:0 auto;padding:58px 0 30px}.intro{grid-template-columns:1.1fr .9fr;align-items:end;gap:clamp(32px,6vw,70px);margin-bottom:42px;display:grid}.eyebrow{color:var(--blue);letter-spacing:.18em;margin:0 0 16px;font-size:10px;font-weight:750}.intro h1{max-width:700px;color:var(--ink);letter-spacing:-.055em;margin:0;font-size:clamp(46px,5.1vw,76px);font-weight:560;line-height:.98}.intro-copy{border-left:2px solid var(--coral);color:#5d6875;max-width:520px;margin:0 0 7px;padding-left:24px;font-size:15px;line-height:1.75}.workspace-grid{border:1px solid var(--line);background:var(--white);border-radius:20px;grid-template-columns:minmax(0,1.55fr) minmax(280px,.65fr);min-width:0;display:grid;overflow:hidden;box-shadow:0 22px 70px #0b1c3312}.upload-panel,.session-panel{min-width:0;padding:30px}.session-panel{border-left:1px solid var(--line);background:#fafbf9}.section-heading,.section-heading>div,.section-heading>div>div,.pipeline-heading,.preview-heading,.file-title-row{align-items:center;display:flex}.section-heading>div,.section-heading>div>div{min-width:0}.section-heading>div>div{flex-direction:column;align-items:flex-start}.section-heading,.pipeline-heading,.preview-heading,.file-title-row{justify-content:space-between}.section-heading{gap:18px;margin-bottom:24px}.section-heading>div{gap:13px}.section-number{width:32px;height:32px;color:var(--blue);font-family:var(--font-geist-mono), monospace;background:#edf6f8;border-radius:50%;flex:0 0 32px;place-items:center;font-size:10px;font-weight:650;display:grid}.section-heading h2,.pipeline-heading h2{letter-spacing:-.02em;margin:0;font-size:16px;font-weight:680}.section-heading p{color:var(--muted);margin:4px 0 0;font-size:11px}.text-button{color:#537180;cursor:pointer;background:0 0;border:0;align-items:center;gap:7px;padding:7px 0;font-size:11px;display:inline-flex}.text-button .info-symbol{flex-basis:17px;width:17px;height:17px;font-size:10px}.dropzone{background:linear-gradient(#ffffffd1,#ffffffd1),repeating-linear-gradient(90deg,#eaf3f5 0 1px,#0000 1px 34px),repeating-linear-gradient(0deg,#eaf3f5 0 1px,#0000 1px 34px);border:1px dashed #aebfc7;border-radius:14px;flex-direction:column;justify-content:center;align-items:center;min-height:310px;transition:border-color .16s,background-color .16s,transform .16s;display:flex;position:relative;overflow:hidden}.dropzone.dragging{border-color:var(--blue);background-color:#edf8fa;transform:scale(.995)}.dropzone input{opacity:0;width:1px;height:1px;position:absolute}.upload-glyph{background:#f9fdfd;border:1.5px solid #7ea3b1;border-radius:5px;width:48px;height:42px;margin-bottom:16px;position:relative}.upload-glyph:before,.upload-glyph:after,.upload-glyph span:before,.upload-glyph span:after{content:"";position:absolute}.upload-glyph:before{background:#eaf5f7;border-bottom:1.5px solid #7ea3b1;border-left:1.5px solid #7ea3b1;width:14px;height:14px;top:-1.5px;right:-1.5px}.upload-glyph:after{background:var(--blue);width:2px;height:14px;top:16px;left:22px}.upload-glyph span:before{border-top:2px solid var(--blue);border-left:2px solid var(--blue);width:9px;height:9px;top:15px;left:18px;transform:rotate(45deg)}.upload-glyph span:after{background:#7ea3b1;width:19px;height:1.5px;bottom:6px;left:14px}.dropzone h3{margin:0;font-size:16px;font-weight:670}.dropzone>p{color:var(--muted);margin:7px 0 18px;font-size:12px}.primary-button,.secondary-button{cursor:pointer;border:0;border-radius:5px;font-weight:650}.primary-button{color:#fff;background:var(--ink);padding:11px 22px;box-shadow:0 6px 18px #08152c24}.primary-button:hover:not(:disabled){background:#132b51}.primary-button:disabled,.secondary-button:disabled,.clear-button:disabled{cursor:not-allowed;opacity:.48}.format-row{gap:7px;margin-top:20px;display:flex}.format-row span{color:#71838c;font-family:var(--font-geist-mono), monospace;background:#fff;border:1px solid #d8e1e3;border-radius:4px;padding:5px 8px;font-size:9px}.session-metrics{border:1px solid var(--line);background:var(--line);grid-template-columns:repeat(3,minmax(0,1fr));gap:1px;margin:2px 0 22px;display:grid}.session-metrics div{background:#fff;min-width:0;padding:15px 11px}.session-metrics strong,.session-metrics span{display:block}.session-metrics strong{font-family:var(--font-geist-mono), monospace;text-overflow:ellipsis;font-size:14px;overflow:hidden}.session-metrics span{color:var(--muted);letter-spacing:.06em;text-transform:uppercase;margin-top:5px;font-size:9px}.pair-status{border-top:1px solid var(--line);border-bottom:1px solid var(--line);gap:11px;padding:15px 0;display:flex}.status-light{background:#aeb7be;border:2px solid #fff;border-radius:50%;flex:0 0 9px;width:9px;height:9px;margin-top:3px;box-shadow:0 0 0 1px #aeb7be}.status-light.complete{background:var(--mint);box-shadow:0 0 0 1px var(--mint)}.pair-status strong{font-size:11px;display:block}.pair-status p{color:var(--muted);margin:5px 0 0;font-size:10px;line-height:1.5}.session-actions{gap:8px;margin-top:22px;display:grid}.secondary-button{color:#fff;background:var(--ink);padding:11px 14px}.clear-button{color:#6f7b86;cursor:pointer;background:0 0;border:0;padding:9px 14px;font-size:11px}.results-section{border:1px solid var(--line);background:#fff;border-radius:18px;min-width:0;margin-top:18px;padding:30px;overflow:hidden}.result-heading{margin-bottom:20px}.result-count{color:#47776c;background:#ebf7f3;border-radius:999px;padding:6px 10px;font-size:10px;font-weight:650}.file-list{gap:8px;display:grid}.file-card{border:1px solid var(--line);background:#fcfdfc;border-radius:11px;grid-template-columns:52px minmax(0,1fr) auto;align-items:start;gap:15px;min-width:0;padding:15px;display:grid}.file-kind{color:#176b84;width:48px;height:48px;font-family:var(--font-geist-mono), monospace;background:#eaf6f8;border-radius:6px;place-items:center;font-size:10px;font-weight:700;display:grid}.kind-vcf{color:#a5483c;background:#fff0ed}.kind-bam{color:#2d6c5d;background:#eaf7f2}.kind-bai{color:#6b5b91;background:#f1edfa}.file-main{min-width:0}.file-title-row{justify-content:flex-start;gap:10px}.file-main h3{text-overflow:ellipsis;white-space:nowrap;margin:1px 0 0;font-size:12px;font-weight:680;overflow:hidden}.file-status{letter-spacing:.05em;text-transform:uppercase;border-radius:999px;padding:4px 7px;font-size:8px;font-weight:700}.file-status.ready{color:#347363;background:#e8f6f1}.file-status.warning{color:#9a563f;background:#fff0e9}.file-main>p{color:#53606c;margin:6px 0 0;font-size:11px}.fact-row{flex-wrap:wrap;gap:5px 15px;margin-top:9px;display:flex}.fact-row span{color:#84909a;font-size:9px;position:relative}.fact-row span+span:before{content:"";background:#bbc4c8;border-radius:50%;width:3px;height:3px;position:absolute;top:50%;left:-9px}.file-size{color:#8b969f;font-family:var(--font-geist-mono), monospace;padding-top:3px;font-size:9px}.variant-preview{background:#f9fbfa;border:1px solid #dce4e5;margin-top:20px;padding:20px}.preview-heading{margin-bottom:14px}.preview-heading .eyebrow{margin-bottom:5px}.preview-heading h3{margin:0;font-size:14px}.preview-heading>span{color:#9b6b61;text-transform:uppercase;letter-spacing:.08em;font-size:9px}.preview-table{border-top:1px solid var(--line)}.preview-row{border-bottom:1px solid var(--line);grid-template-columns:.7fr .7fr 1.6fr;display:grid}.preview-row span{color:#586673;padding:10px 8px;font-size:10px}.preview-header span{color:#84919a;letter-spacing:.07em;text-transform:uppercase;font-size:8px;font-weight:700}.mono{font-family:var(--font-geist-mono), monospace}.pipeline-section{color:#eef4fa;background:radial-gradient(circle at 80% 0, #1b90b429, transparent 30%), var(--navy);border-radius:22px;margin-top:70px;padding:44px 42px 48px;overflow:hidden}.pipeline-heading{margin-bottom:32px}.pipeline-heading .eyebrow{color:var(--cyan);margin-bottom:6px}.pipeline-heading h2{color:#fff;font-size:22px}.text-button.dark{color:#b9cadc}.pipeline-track{grid-template-columns:repeat(5,minmax(0,1fr));gap:14px;display:grid}.stage-card{border:1px solid var(--line-dark);background:#ffffff09;border-radius:12px;min-width:0;min-height:190px;padding:18px;transition:border-color .16s,transform .16s,background .16s;position:relative}.stage-card:hover{background:#38bde80f;border-color:#38bde875;transform:translateY(-3px)}.stage-topline{border-bottom:1px solid var(--line-dark);justify-content:space-between;align-items:center;padding-bottom:15px;display:flex}.stage-topline span{color:var(--cyan);font-family:var(--font-geist-mono), monospace;font-size:10px}.stage-topline small{color:#7f94ae;font-size:9px}.stage-card h3{color:#fff;margin:22px 0 10px;font-size:15px;font-weight:620}.stage-card p{color:#8fa1b8;margin:0;font-size:10px;line-height:1.55}.connector{z-index:2;border:1px solid var(--line-dark);width:27px;height:27px;color:var(--cyan);background:var(--navy);border-radius:50%;place-items:center;font-size:13px;display:grid;position:absolute;top:88px;right:-21px}footer{color:#8a959e;letter-spacing:.06em;text-transform:uppercase;justify-content:space-between;padding:28px 2px 0;font-size:9px;display:flex}[data-tooltip]{position:relative}[data-tooltip]:after{z-index:80;color:#eef5fb;content:attr(data-tooltip);width:max-content;max-width:min(280px,100vw - 28px);font-family:var(--font-geist-sans), Arial, sans-serif;letter-spacing:0;opacity:0;pointer-events:none;text-align:left;text-transform:none;white-space:normal;background:#101f37;border-radius:5px;padding:9px 11px;font-size:10px;font-style:normal;font-weight:450;line-height:1.45;transition:opacity .13s,transform .13s;position:absolute;bottom:calc(100% + 10px);left:50%;transform:translate(-50%,4px);box-shadow:0 8px 25px #030d1b38}[data-tooltip]:hover:after,[data-tooltip]:focus-visible:after{opacity:1;transform:translate(-50%)}.sidebar [data-tooltip]:after{top:50%;bottom:auto;left:calc(100% + 10px);transform:translate(4px,-50%)}.sidebar [data-tooltip]:hover:after,.sidebar [data-tooltip]:focus-visible:after{transform:translateY(-50%)}.pipeline-track [data-tooltip]:after{bottom:calc(100% + 12px)}.topbar-actions [data-tooltip]:after,.section-heading>.text-button[data-tooltip]:after,.pipeline-heading .text-button[data-tooltip]:after,.lab-heading .text-button[data-tooltip]:after{left:auto;right:0;transform:translateY(4px)}.topbar-actions [data-tooltip]:hover:after,.topbar-actions [data-tooltip]:focus-visible:after,.section-heading>.text-button[data-tooltip]:hover:after,.section-heading>.text-button[data-tooltip]:focus-visible:after,.pipeline-heading .text-button[data-tooltip]:hover:after,.pipeline-heading .text-button[data-tooltip]:focus-visible:after,.lab-heading .text-button[data-tooltip]:hover:after,.lab-heading .text-button[data-tooltip]:focus-visible:after{transform:translateY(0)}.modal-backdrop{z-index:100;-webkit-backdrop-filter:blur(5px);backdrop-filter:blur(5px);background:#040c19b3;place-items:center;padding:28px;display:grid;position:fixed;inset:0}.method-modal{background:#fff;width:min(820px,100%);max-height:min(860px,100vh - 56px);overflow:auto;box-shadow:0 30px 100px #0000004d}.modal-header{z-index:2;border-bottom:1px solid var(--line);-webkit-backdrop-filter:blur(8px);backdrop-filter:blur(8px);background:#fffffff5;justify-content:space-between;align-items:center;padding:26px 30px 22px;display:flex;position:sticky;top:0}.modal-header .eyebrow{margin-bottom:7px}.modal-header h2{letter-spacing:-.035em;margin:0;font-size:25px}.modal-close{border:1px solid var(--line);cursor:pointer;background:#fff;border-radius:50%;place-items:center;width:36px;height:36px;font-size:23px;font-weight:300;display:grid}.modal-body{padding:28px 30px 34px}.method-intro{background:#f1faf7;border:1px solid #cfe4df;grid-template-columns:auto 1fr;align-items:start;gap:16px;padding:18px;display:grid}.method-badge{color:#307968;font-family:var(--font-geist-mono), monospace;border:1px solid #afd6cb;border-radius:3px;padding:5px 7px;font-size:9px;font-weight:700}.method-intro p{color:#49665f;margin:0;font-size:12px;line-height:1.65}.method-steps{gap:0;margin:28px 0;padding:0;list-style:none;display:grid}.method-steps li{grid-template-columns:38px 1fr;gap:16px;padding:0 0 22px;display:grid}.method-steps li>span{width:34px;height:34px;color:var(--blue);font-family:var(--font-geist-mono), monospace;border:1px solid #c8d5da;border-radius:50%;place-items:center;font-size:10px;display:grid}.method-steps h3{margin:4px 0 7px;font-size:14px}.method-steps p{color:#66727e;margin:0;font-size:11px;line-height:1.65}.method-steps code{color:#315a67;font-family:var(--font-geist-mono), monospace;background:#edf4f5;margin-top:10px;padding:7px 9px;font-size:10px;display:inline-block}.method-warning{border-left:3px solid var(--coral);background:#fff6f3;padding:18px 20px}.method-warning strong{color:#7b4339;font-size:12px}.method-warning p{color:#7a5d58;margin:7px 0 0;font-size:11px;line-height:1.65}.workspace-grid,.results-section,.evidence-lab,.pipeline-section{scroll-margin-top:92px}.evidence-lab{min-width:0;margin-top:70px}.lab-heading{justify-content:space-between;align-items:flex-end;gap:28px;margin-bottom:26px;display:flex}.lab-heading>div{min-width:0}.lab-heading .eyebrow{margin-bottom:9px}.lab-heading h2{max-width:760px;color:var(--ink);letter-spacing:-.045em;margin:0;font-size:clamp(27px,3.1vw,42px);font-weight:590;line-height:1.08}.lab-heading>div>p:last-child{color:#687581;max-width:720px;margin:13px 0 0;font-size:13px;line-height:1.65}.simulator-grid{grid-template-columns:repeat(2,minmax(0,1fr));align-items:start;gap:18px;min-width:0;display:grid}.simulator-card{background:#fffffff0;border:1px solid #dbe1e3;border-radius:18px;min-width:0;padding:26px;overflow:hidden;box-shadow:0 18px 55px #0b1c330e}.simulator-title{justify-content:space-between;align-items:flex-start;gap:16px;margin-bottom:24px;display:flex}.simulator-title>div{min-width:0}.simulator-index{color:var(--blue);font-family:var(--font-geist-mono), monospace;letter-spacing:.13em;margin-bottom:7px;font-size:9px;font-weight:700;display:block}.simulator-title h3{letter-spacing:-.025em;margin:0;font-size:18px;font-weight:650}.quality-badge,.evidence-badge{letter-spacing:.03em;white-space:nowrap;border-radius:999px;flex:none;padding:6px 9px;font-size:9px;font-weight:680}.quality-badge.high,.evidence-badge.balanced{color:#2c715f;background:#e7f6f1}.quality-badge.medium{color:#8b6724;background:#fff6dc}.quality-badge.low,.evidence-badge.attention{color:#9a4c3c;background:#fff0eb}.sim-controls{gap:18px 20px;min-width:0;display:grid}.sim-controls.two-columns,.variant-controls{grid-template-columns:repeat(2,minmax(0,1fr))}.range-field{gap:9px;min-width:0;display:grid}.range-field>span{justify-content:space-between;align-items:center;gap:10px;display:flex}.range-field b{color:#5d6975;font-size:10px;font-weight:620}.range-field output{color:var(--ink);font-family:var(--font-geist-mono), monospace;white-space:nowrap;font-size:10px;font-weight:700}.range-field input[type=range]{width:100%;height:4px;accent-color:var(--blue);cursor:pointer;margin:0}.sim-metrics{background:#dfe5e6;border:1px solid #dfe5e6;border-radius:10px;grid-template-columns:repeat(3,minmax(0,1fr));gap:1px;margin:22px 0;display:grid;overflow:hidden}.sim-metrics>div{background:#f9fbfa;min-width:0;padding:13px 12px}.sim-metrics span,.sim-metrics strong{text-overflow:ellipsis;display:block;overflow:hidden}.sim-metrics span{color:#84909a;letter-spacing:.06em;text-transform:uppercase;margin-bottom:6px;font-size:8px}.sim-metrics strong{font-family:var(--font-geist-mono), monospace;white-space:nowrap;font-size:13px}.quality-visual{color:#dce9f4;background:#0c1a32;border-radius:12px;padding:16px;overflow:hidden}.quality-scale,.pileup-axis{color:#8297ae;font-family:var(--font-geist-mono), monospace;letter-spacing:.04em;text-transform:uppercase;justify-content:space-between;align-items:center;gap:12px;font-size:8px;display:flex}.quality-track{grid-template-columns:repeat(28,minmax(10px,1fr));gap:3px;margin:17px 0 12px;display:grid;overflow:hidden}.quality-track span{color:#dff7ff;height:27px;font-family:var(--font-geist-mono), monospace;background:#38bde84d;border-radius:3px;place-items:center;font-size:8px;display:grid}.quality-track.quality-medium span:nth-child(4n),.quality-track.quality-medium span:nth-child(7n){color:#fff2cf;background:#efb44766}.quality-track.quality-low span:nth-child(2n),.quality-track.quality-low span:nth-child(5n){color:#ffe4de;background:#ff826e70}.accuracy-line{background:#ffffff14;border-radius:999px;height:3px;overflow:hidden}.accuracy-line span{border-radius:inherit;background:linear-gradient(90deg, var(--cyan), var(--mint));height:100%;transition:width .18s;display:block}.simulation-note,.lab-disclaimer{color:#7c8892;font-size:10px;line-height:1.55}.simulation-note{margin:14px 0 0}.lab-disclaimer{margin:13px 2px 0}.preset-row{flex-wrap:wrap;gap:7px;margin:-7px 0 20px;display:flex}.preset-row button{color:#697681;cursor:pointer;background:#f8faf9;border:1px solid #d9e0e2;border-radius:7px;padding:7px 10px;font-size:9px;transition:color .14s,border-color .14s,background .14s}.preset-row button:hover{color:#215c70;background:#f0f8fa;border-color:#9fc8d5}.pileup{background:#0c1a32;border-radius:12px;min-width:0;padding:15px;overflow:hidden}.pileup-axis b{color:#c7d8e7;font-weight:600}.reference-lane{border-top:1px solid #ffffff17;border-bottom:1px solid #ffffff17;grid-template-columns:repeat(9,1fr);gap:2px;margin:12px 0 10px;padding:5px 10%;display:grid}.reference-lane span,.reference-lane strong{color:#8097ad;font-family:var(--font-geist-mono), monospace;text-align:center;font-size:8px;font-weight:500}.reference-lane strong{color:var(--coral)}.read-stack{gap:3px;min-height:140px;padding:5px 0;display:grid;position:relative}.variant-guide{z-index:0;background:#ff826e52;width:1px;position:absolute;top:0;bottom:0;left:50%}.sim-read{z-index:1;width:var(--read-width);height:4px;margin-left:var(--read-left);background:#577e9aa3;border-radius:999px;display:block;position:relative}.sim-read.reverse{opacity:.67}.sim-read.alt{background:#58cbb0b8}.sim-read b{top:50%;left:var(--marker-left);color:#132239;background:var(--coral);width:12px;height:12px;font-family:var(--font-geist-mono), monospace;border-radius:3px;place-items:center;font-size:7px;display:grid;position:absolute;transform:translate(-50%,-50%)}.evidence-message{align-items:flex-start;gap:9px;margin-top:13px;display:flex}.evidence-message>span{border-radius:50%;flex:0 0 8px;width:8px;height:8px;margin-top:4px}.evidence-message>span.balanced{background:var(--mint)}.evidence-message>span.attention{background:var(--coral)}.evidence-message p{color:#697680;margin:0;font-size:10px;line-height:1.55}.simulation-method{grid-template-columns:repeat(2,minmax(0,1fr));gap:12px;margin:2px 0 28px;display:grid}.simulation-method>div{background:#f7faf9;border:1px solid #dce5e7;border-radius:10px;min-width:0;padding:16px}.simulation-method span{color:var(--blue);font-family:var(--font-geist-mono), monospace;font-size:8px;font-weight:700}.simulation-method h3{margin:7px 0;font-size:12px}.simulation-method p{color:#6b7782;margin:0;font-size:10px;line-height:1.6}.simulation-method code{color:#315a67;background:#e8f1f2;padding:2px 4px;font-size:9px}@media (width<=1050px){:root{--sidebar:220px}.content{width:min(100% - 44px,1120px)}.workspace-grid,.simulator-grid{grid-template-columns:1fr}.session-panel{border-top:1px solid var(--line);border-left:0}.pipeline-track{grid-template-columns:repeat(2,1fr)}.connector{display:none}}@media (width<=760px){:root{--sidebar:0px}.sidebar{flex-direction:row;align-items:center;gap:16px;width:100%;min-height:auto;padding:16px 18px;position:relative}.brand{margin:0 auto 0 0}.brand-mark{width:34px;height:34px}.sidebar nav,.sidebar-spacer,.sidebar-note,.sidebar-method{display:none}.profile{border:0;padding:0}.profile>span:last-child{display:none}main{margin-left:0}.topbar{height:58px;padding:0 20px}.topbar>div:first-child{display:none}.topbar-actions{justify-content:flex-end;width:100%}.content{width:calc(100% - 32px);padding-top:42px}.intro{grid-template-columns:1fr;gap:26px;margin-bottom:36px}.intro h1{font-size:clamp(44px,13vw,64px)}.intro-copy{padding-left:16px}.upload-panel,.session-panel,.results-section{padding:22px 18px}.lab-heading{flex-direction:column;align-items:flex-start;gap:12px}.lab-heading .text-button{align-self:flex-start}.simulator-card{padding:21px 18px}.simulator-title,.section-heading{align-items:flex-start}.section-heading>.text-button{display:none}.dropzone{text-align:center;min-height:290px;padding:20px}.pipeline-section{margin-top:46px;padding:30px 20px}.pipeline-track{grid-template-columns:1fr}.stage-card{min-height:160px}.pipeline-heading{align-items:flex-end}.pipeline-heading .text-button{font-size:0}.pipeline-heading .text-button .info-symbol{font-size:10px}.file-card{grid-template-columns:44px minmax(0,1fr)}.file-kind{width:42px;height:42px}.file-size{display:none}.file-title-row{flex-direction:column;align-items:flex-start}.preview-row{grid-template-columns:.8fr .7fr 1.5fr}.preview-row span{overflow-wrap:anywhere}footer{flex-direction:column;gap:14px}.modal-backdrop{place-items:stretch stretch;padding:0}.method-modal{width:100%;max-height:100vh}.modal-header,.modal-body{padding-left:20px;padding-right:20px}.method-intro,.simulation-method{grid-template-columns:1fr}[data-tooltip]:after{display:none}}@media (width<=520px){.content{width:calc(100% - 24px)}.intro h1{font-size:clamp(39px,12.5vw,52px)}.intro-copy{font-size:13px}.section-heading>div{min-width:0}.section-heading h2{overflow-wrap:anywhere}.session-metrics{grid-template-columns:1fr}.format-row{flex-wrap:wrap;justify-content:center}.sim-controls.two-columns,.variant-controls,.sim-metrics{grid-template-columns:1fr}.simulator-title{flex-direction:column}.quality-track{grid-template-columns:repeat(14,minmax(10px,1fr))}.quality-track span:nth-child(n+15){display:none}.pileup-axis{flex-direction:column;align-items:flex-start;gap:4px}.preview-table{overflow-x:auto}.preview-row{min-width:520px}.pipeline-section{padding-left:16px;padding-right:16px}.modal-header h2{font-size:21px}}@media (prefers-reduced-motion:reduce){*,:before,:after{scroll-behavior:auto!important;transition-duration:.01ms!important}}